The barrage of rockets leaving Gaza and airstrikes coming into the territory continued almost non-stop throughout the day.
A statement described the airstrikes as "defensive."
The R9X variant of the AGM-114 Hellfire is a non-explosive weapon best be described as a 100-pound flying switchblade.
The strikes employed twice as many weapons used as in the response to a Syrian chemical attack last year.
The Afghanistan conflict just recorded the most U.S. airstrikes in a single month in nearly a decade.
A statement said an Afghan unit on the ground had told coalition forces that the area was clear of friendly forces.
U.S. Africa Command says that there have been no civilian casualties as a result of U.S. air strikes targeting al-Shabaab.
President Trump moved to rescind part of an Obama-era order requiring the publication of a report on civilian casualties.
U.S. fighters, bombers, attack aircraft and drones released 7,362 weapons over Afghanistan in 2018.
In addition to U.S. and coalition strikes, Iraqi fighter aircraft have also attacked ISIS targets inside Syria recently.
Air Force Lt. Col. Rob Sweet retired this week as the deputy commander of the 476th Fighter Group at Moody Air Force Base.
It was the second long-range autonomous transit through the Navy's Ghost Fleet Overlord program.
Boeing Co. is behind schedule on two new Air Force One aircraft.
Capt. Durwood "Hawk" Jones of the 115th Fighter Wing out of Truax Field Air National Guard Base was instantly killed.
Maj. Gen. Robert Castellvi was in charge of the 1st Marine Division when an AAV sank off San Diego's coast last July.